Health
06 Jun 2025
Statins may reduce risk of death by 39% for patients with life-threatening sepsis
It has been suggested that statins could boost the chances of survival of patients with sepsis because of their multipronged effects on inflammation. Here, researchers from China used the MIMIC-IV database to perform a retrospective cohort study on two large, matched groups: critically ill patients with sepsis in the Beth Israel Deaconess Medical Center who received standard of care with or without statins. The 28-day all-cause mortality was 39% lower in relative terms [an absolute reduction from 23.4% to 14.3%] in the statin group, suggesting a protective effect. Previous randomized controlled trials that didn’t find any such benefit might have been too small or have had other weaknesses. The present results need to be confirmed in a large, well-designed randomized clinical trial.
