REVIEW article
Front. Pharmacol.
Sec. Translational Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1604965
This article is part of the Research TopicAdvancements in Bioactive Nanomaterials for Disease ManagementView all articles
Functional Nanomaterials for Enhanced Tumor Photothermal Therapy -the Mechanisms and Applications
Provisionally accepted
Xiao Xiao1*
Xiaoling Han1Guohai Feng1Xiaoman Li1Shuyi Mo1Caijing Xu1Jiahui Yan1Li Yu1Rong Zhang1Ying Jin1
Li Deng2*- 1Jilin Medical University, Jilin, China
- 2The People’s Hospital of Gaozhou, Gaozhou, China
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Photothermal therapy (PTT) offers revolutionary breakthroughs in tumor treatment due to its minimally invasive nature, high selectivity and efficiency.Photothermal therapy is a method of using laser irradiation (near-infrared light) to convert light energy into heat, reaching a relatively high temperature to kill tumor cells. Efficient and stable photothermal conversion materials are the key factors in PTT. There are inorganic and organic nanomaterials used in photothermal therapy.Through chemical modification of them, the functions of targeted drug delivery and combination therapy can be achieved. This work generalizes the features, excellent performance and therapeutic effects of photothermal conversion nanomaterials such as polydopamine (PDA), semiconductor nanoparticles (SNPs), Au nanomaterials, palladium nanosheets (PdNs), and carbon nanomaterials. Their functions and the advantages in photothermal therapy, tumor targeting and inactivation, and the mechanisms of nanophotothermal therapy are summarized. By continuously improving the performance and treatment methods of nanomaterials, more efficient, safe and minimally invasive solutions for tumor treatment are expected.
Keywords: nanomaterial, Polymer nanoparticles, Nanophotothermal agent, photothermal therapy, tumor therapy
Received: 02 Apr 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Xiao, Han, Feng, Li, Mo, Xu, Yan, Yu, Zhang, Jin and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiao Xiao, Jilin Medical University, Jilin, China
Li Deng, The People’s Hospital of Gaozhou, Gaozhou, 525200, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.